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Evaluation of Antidiabetic Activity of Carnosol (Phenolic Diterpene in Rosemary) in Streptozotocin-Induced Diabetic Rats

[ Vol. 17 , Issue. 1 ]

Author(s):

Saeed Samarghandian, Abasalt Borji and Tahere Farkhondeh   Pages 11 - 17 ( 7 )

Abstract:


Background: Carnosol (CS) is an ortho-diphenolic diterpene in rosemary with great antioxidant potential. This study was designed to investigate the hypolipidemic, anti-oxidant, and anti-diabetic activities of CS.

Methods: In our experiment, the rats were divided into the following groups of 8 animals each: control, untreated diabetic, three CS (1, 5, 10 mg/kg/day)-treated diabetic groups. On the first day of the study, the diabetic groups were given streptozotocin (STZ) in a single intraperitoneal (i.p.) injection at a dose of 60 mg/kg for induction of diabetes. CS was injected (i.p.) to the treatment groups from 3 days after STZ administration during a period of 4 weeks. At the end of the experimental period, we assessed the serum levels of glucose, IL-6, TNF-α, malondialdehyde (MDA), glutathione–s transferase (GST), superoxide dismutase (SOD), catalase (CAT) activities, triglycerides (TG), total cholesterol (TC), low density lipoprotein (LDL-C), and high density lipoprotein (HDL-C).

Results: The results indicated that STZ caused an elevation of serum glucose, IL-6, TNF-α, MDA, TG, TC, LDL-C, and it also made a reduction of serum GST, SOD, CAT, and HDL-C (p<0.001). The findings showed amelioration in the serum glucose, IL-6, TNF-α, MDA, TG, TC, LDL-C, GST, SOD, CAT, and HDL-C in the CS-treated diabetic groups versus the untreated group, in a dose dependent manner (p < 0.001).

Conclusion: In conclusion, the present investigation proposes that CS may be improved diabetes and its complications by modulation of oxidative stress and inflammatory responses.

Keywords:

Carnosol, diabetes, oxidative indices, inflammation, streptozotocin, rat.

Affiliation:

Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Department of Immunogenetics, BuAli Research Institute, Mashhad University of Medical Sciences, Mashhad

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