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Synergism Effects of Ursolic Acid Supplementation on the Levels of Irisin, C-reactive Protein, IL-6, and TNF-α During High-intensity Resistance Training in Low Activity Men

[ Vol. 20 , Issue. 2 ]

Author(s):

Ehsan Asghari, Amir Rashidlamir*, Seyyed R. A. Hosseini, Mahtab Moazzami, Saeed Samarghandian and Tahereh Farkhondeh   Pages 138 - 144 ( 7 )

Abstract:


Background: Ursolic Acid (UA) is a pentacyclic triterpenoid carboxylic acid which is extracted from plants. UA may enhance the effect of Resistance Training (RT) in human.

Objective: Current research was designed to show the effect of High-Intensity Resistance Training (HIRT) in the presence or absence of UA on the serum levels of irisin, CRP, IL-6 and TNF-α in the low activity men.

Methods: The study included twenty-two healthy male HIRT with placebo, supplementation, and HIRT in the presence of UA supplementation. The two groups received eight-week intervention including 2 sets of 8 exercises, with 8∼10 repetitions at 70∼75% of 1 repetition maximum and a 2 min rest interval between sets, performed 3 times/week. Placebo or UA orally was evaluated as 1 capsule 3 times/day during 8 weeks. The subsequent factors were measured post- and preintervention: C-Reactive Protein (CRP), Irisin, Tumor Necrotic Factor (TNF-α) and Interleukin-6 (IL-6).

Results: UA supplementation significantly increased the plasma levels of irisin in the HIRT+UA group versus the HIRT+P group (p<0.05). UA treatment also dramatically decreased the plasma levels of CRP, IL-6, and TNF-α in the HIRT+UA group versus the HIRT+P group (p<0.05).

Conclusion: The current data showed that UA-induced an increase in serum irisin and reduction of CRP, IL-6, and TNF-α may have beneficial effects as a chemical for increasing of the effects of HIRT in low activity men.

Keywords:

Ursolic acid, Irisin, C-reactive protein, IL-6, TNF-α, resistance training.

Affiliation:

Department of Physical Education and Sport Sciences, Faculty of Sport Science, Ferdowsi University of Mashhad, Mashhad, Department of Physical Education and Sport Sciences, Faculty of Sport Science, Ferdowsi University of Mashhad, Mashhad, Department of Physical Education and Sport Sciences, Faculty of Sport Science, Ferdowsi University of Mashhad, Mashhad, Department of Physical Education and Sport Sciences, Faculty of Sport Science, Ferdowsi University of Mashhad, Mashhad, Department of Physical Education and Sport Sciences, Faculty of Sport Science, Ferdowsi University of Mashhad, Mashhad, Department of Physical Education and Sport Sciences, Faculty of Sport Science, Ferdowsi University of Mashhad, Mashhad



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